Glucocorticoid dynamics: insights from mathematical, experimental and clinical studies
نویسندگان
چکیده
A pulsatile pattern of secretion is a characteristic of many hormonal systems, including the glucocorticoid-producing hypothalamic–pituitary–adrenal (HPA) axis. Despite recent evidence supporting its importance for behavioral, neuroendocrine and transcriptional effects of glucocorticoids, there has been a paucity of information regarding the origin of glucocorticoid pulsatility. In this review we discuss the mechanisms regulating pulsatile dynamics of the HPA axis, and how these dynamics become disrupted in disease. Our recent mathematical, experimental and clinical studies show that glucocorticoid pulsatility can be generated and maintained by dynamic processes at the level of the pituitary–adrenal axis, and that an intra-adrenal negative feedback may contribute to these dynamics. Key Words
منابع مشابه
60 YEARS OF NEUROENDOCRINOLOGY: Glucocorticoid dynamics: insights from mathematical, experimental and clinical studies.
A pulsatile pattern of secretion is a characteristic of many hormonal systems, including the glucocorticoid-producing hypothalamic-pituitary-adrenal (HPA) axis. Despite recent evidence supporting its importance for behavioral, neuroendocrine and transcriptional effects of glucocorticoids, there has been a paucity of information regarding the origin of glucocorticoid pulsatility. In this review ...
متن کاملStructural dynamics in northern Atlas of Tunisian, Jendouba area: insights from geology and gravity data
This paper presents a new interpretation of the geometry of Triassic alignment of J. Sidi Mahdi –J. Zitoun in Medjerda Valley Plain (Northern Tunisia) based on detailed analysis of gravity and seismic reflection data. The main results of gravity analysis do not show a distinguish gravity anomaly over Triassic evaporites bodies. The positive gravity anomaly seems to be related to the entire stru...
متن کاملA review on West African Ebola epidemic dynamics models
Background and aims: The world is threatened by disease outbreak that reaches a public health emergency of international concern, studies to inform public and agencies for effective containment strategy are necessary. Several studies provided vital information of the dynamics and control of Ebola epidemic outbreak in West Africa. Methodologies and techniques in those researches...
متن کاملGlucocorticoid-induced osteoporosis.
Glucocorticoid-induced osteoporosis is one of the most important side-effects of glucocorticoid use, leading to an increased fracture risk. In this review, recent advances in the understanding of the mechanisms of glucocorticoid-induced osteoporosis are summarised. Methods to identify persons at risk for fractures are discussed, as well as the new ACR recommendations for the prevention and trea...
متن کاملDesign, Modeling, Implementation and Experimental Analysis of 6R Robot (TECHNICAL NOTE)
Design, modeling, manufacturing and experimental analysis of a six degree freedom robot, suitable for industrial applications, has been described in this paper. The robot was designed on the assumption that, each joint has an independent DC motor actuator, with gear reduction and measuring sensor for angular joint position. Mechanical design of the robot was done using Mechanical Desktop and ma...
متن کامل